Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy.

Zhaobing Tang,Xiong Wang,Juan Zhang,Peng Wang,Haifeng Pei,Chao Dong,Liang-Jun Yan

doi:10.1155/2022/5913374

Abstract

As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy.

Highlights

Diabetes is a chronic metabolic disease that threatens the health of hundreds of millions
Several mechanisms are involved in the pathogenesis of diabetic cardiomyopathy (DCM), among which oxidative stress (OS) plays a causative role in DCM pathophysiology
There are various kinds of OS-related signaling pathways involved in the pathogenesis of DCM

Summary

Introduction

Diabetes is a chronic metabolic disease that threatens the health of hundreds of millions. Over 90% are type 2 diabetes mellitus (T2DM), which is responsible for more than 6 million deaths in 2021 [1]. Diabetic cardiovascular diseases (DCVDs) are the leading causes of death in diabetic patients, accounting for more than 50% [2]. As a serious type of DCVD, DCM is defined as a specific disease with cardiac structural abnormalities and dysfunctions in diabetic patients independent of uncontrolled hypertension, coronary artery disease, significant valvular disease, and congenital heart disease [5, 6], but there is still no universally accepted definition and no authoritative epidemiological data on morbidity and mortality [7]. We focus on recent studies and summarize the OS-related signaling pathways associated with DCM

ROS Generation and Its Role in DCM Progression

Oxidative Stress Signalings Involved in the Pathogenesis of DCM

Conclusion

Findings

Conflicts of Interest