Oxidative stress parameters and antioxidant enzyme levels in patients with central serous chorioretinopathy.

Abstract

Central serous chorioretinopathy (CSC) is a posterior segment disease caused by macular serous detachment as a result of inflammation and oxidative stress due to hypoperfusion of choriocapillaris. The aim of the study was to assess the oxidant/antioxidant balance in CSC.s. The plasma levels of malonyl dialdehyde (MDA), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO), catalase (CAT), and xanthine oxidase (XO) were assessed in 21 patients with CSC (group S) and in 23 individuals without any eye pathology as the control group (group C). Furthermore, the disease was staged through routine opthalmologic examination as well as optic coherence tomography (OCT). MDA levels were significantly higher in group S (25.36 ± 4.51 nmol/ml), when compared with group C (22.79 ± 3.23 nmol/ml) (P = 0.035). In addition, the levels of CAT were significantly lower in group S (8.28 ± 5.85 U/ml) when compared to group C (14.02 ± 8.61 (P = 0.014). Prevention of the oxidative injury may be considered among the associated treatment options under the light of the changes detected in the oxidative/antioxidative parameters.