Abstract
To evaluate lenticular oxidative stress in rat menopausal models. Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p >0.05). The mean TOS values were similar between the groups (p >0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p <0.001). Our results indicate that menopause may not promote cataract formation.
Highlights
Cataract is the most common cause of treatable blindness world wide
10 formaram o grupo controle menopausa (Grupo 2), 10 ratas receberam injeção diária de metilprednisolona até ao final do estudo (Grupo 3) e 10 ratas receberam estreptozotocina por via intraperitoneal para induzir diabetes mellitus (Grupo 4)
Some reports have shown the protective effect of estrogen against cataractogenesis[5,6]
Summary
Cataract is the most common cause of treatable blindness world wide. research related to the etiologic factors of cataractogenesis is always popular. Some well-known systemic conditions such as diabetes mellitus (DM) and systemic steroid intake promote cataract formation[1,2,3,4]. It is controversial, some reports have shown the protective effect of estrogen against cataractogenesis[5,6]. Accu mulation of oxidized lens components and decreased capacity of repair mechanisms promote cataractogenesis in several conditions such as aging and DM[8,9]. We used a practical, reliable, and effective method of oxidative stress analysis that measures total oxidant status (TOS) and total antioxidant capacity (TAC) in the lens[10,11]
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