Oxidative Stress in Pregnancy

Abstract

The aim of the study was to evaluate oxidative stress in uncomplicated pregnancy by determining the serum malondialdehyde (MDA) and ceruloplasmin (Cp) levels. The study was performed on 100 women attending the antenatal outpatient department of Sree Balaji Medical college and Hospital, Chromepet. Serum MDA and Cp levels were measured in the venous blood samples taken in the first and second trimesters of pregnancy. Serum Malondialdehyde was estimated by manual method of Thiobarbituric reactive substances 5 . Serum Ceruloplasmin level was estimated manually by Paraphenylene diamine method 6 . The results were compared between the first and second trimester. MDA levels were high in the second trimester compared to the first trimester (with a p value=0.01). Cp levels were high in the second trimester compared to the first trimester (with a p value=0.01).The conclusion of the research were the pregnant women in the second trimester have increased level of oxidative stress.