Abstract
Objective Coronary artery bypass grafting (CABG) represents the significant source of increased oxidative stress (OS). We aimed to follow the OS status parameters (i.e., ischemia-modified albumin (IMA), malondialdehyde (MDA), superoxide anion, prooxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS), and superoxide-dismutase (SOD)) change through the predefined study times in two different surgical procedures, i.e., cardiopulmonary bypass (CPB) and off-pump coronary artery bypass grafting (OPCAB). Additionally, we aimed to investigate those OS status parameters in specific study times according to SYNTAX score (SS), an established angiographic score for evaluating the extensity and severity of coronary artery disease. Patients and Methods. A total of 107 patients that were planned to undergo CABG were included (i.e., 47 patients in OPCAB and 60 patients in CPB group). Blood samples were taken at 6 time intervals: before surgery (t1), immediately after intervention (t2), 6 h (t3), 24 h (t4), 48 h (t5), and 96 h after termination of the operation (t6). Results IMA levels were higher in CPB than that in OPCAB baseline and rose in CPB group in t2 point. TOS decreased in both study groups, compared to baseline values, but without statistical significance. Superoxide anion and PAB significantly increased in t3-t6 study times, in both groups. MDA significantly increased only in CPB group in t5 and t6 interval. MDA was significantly higher in CPB group compared to OPCAB in t6 study point. CPB patients had significantly lower TAS compared to OPCAB patients at the beginning and in t2 and t3 study points. They also had significantly lower SOD activities compared to OPCAB, baseline, and in several study points. Moreover, TAS, SOD, and TAS/TOS ratio were significantly lower, whereas PAB and TOS/TAS were significantly higher in patients with high SS compared to corresponding groups. SOD activity, IMA, and TAS level were the best predictors of high SS. Conclusion CPB patients were in more severe ischemia baseline than OPCAB group and IMA rose in CPB patients immediately after the surgery end, but not later. Also, the antioxidant status was significantly lower, whereas the prooxidant status was significantly higher in patients with high SS compared to corresponding groups. SOD activity, IMA, and TAS level were the best predictors of CAD (as determined with SS), showing that SOD and IMA had very good discriminatory capability towards higher SS status.
Highlights
It is well known that cardiovascular disease is the leading cause of increased morbidity and mortality worldwide
Attempts have been made to avoid the cardiopulmonary bypass (CPB) deleterious effects and ischemia-reperfusion injury and to reduce the postoperative complications [4] questioning if off-pump coronary artery bypass grafting (OPCAB) on the beating heart may lead to diminishing the oxidative stress (OS) [5] and reduce the rate of morbidity and mortality compared with conventional on-pump CABG (i.e., CPB) [6, 7]
The results of the current study revealed that patients with high SYNTAX score (SS) exhibited pronounced redox imbalance reflected by increased prooxidant species, while reduced antioxidant elements compared to patients with low and intermediate SS
Summary
It is well known that cardiovascular disease is the leading cause of increased morbidity and mortality worldwide. Attempts have been made to avoid the CPB deleterious effects and ischemia-reperfusion injury and to reduce the postoperative complications [4] questioning if off-pump coronary artery bypass grafting (OPCAB) on the beating heart may lead to diminishing the OS [5] and reduce the rate of morbidity and mortality compared with conventional on-pump CABG (i.e., CPB) [6, 7]. These data are inconclusive since other studies report the opposite results [8, 9]
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