Abstract
Abstract Purpose The lens epithelium is the primary target in solar photooxidation. Thioltransferase is a repair enzyme capable of reactivating oxidized critical proteins and enzymes in the cells. Methods Primary lens epithelial cell cultures from wild type and thioltransferase knockout mice were exposed to various doses of UV radiation or hydrogen peroxide. The short‐term reaction pattern of several glutathione‐related enzymes were investigated, as well as long‐term growth rate and cell adhesion. Results UV radiation induces a reaction pattern comparable to that of hydrogen peroxide, with initial increase or decrease in activity of antioxidative enzymes, and a subsequent recovery within 1‐2 hours. Low dose UVR exposure induces cell stimulating effects similar to treatment with low peroxide concentration. Conclusion Oxidative stress from peroxide and UVR might be channeled through same oxidant cellular pathway.
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