Oxidative stress in hepatitis C infected end-stage renal disease subjects

Mehmet Horoz,Cengiz Bolukbas,Filiz F Bolukbas,Ozcan Erel,Sahbettin Selek,Ahmet O Koylu,Mehmet Aslan

doi:10.1186/1471-2334-6-114

Abstract

BackgroundBoth uremia and hepatitis C infection is associated with increased oxidative stress. In the present study, we aimed to find out whether hepatitis C infection has any impact on oxidative stress in hemodialysis subjects.MethodsSixteen hepatitis C (+) hemodialysis subjects, 24 hepatitis C negative hemodialysis subjects and 24 healthy subjects were included. Total antioxidant capacity, total peroxide level and oxidative stress index were determined in all subjects.ResultsTotal antioxidant capacity was significantly higher in controls than hemodialysis subjects with or without hepatitis C infection (all p < 0.05/3), while total peroxide level and oxidative stress index were significantly lower (all p < 0.05/3). Hepatitis C (-) hemodialysis subjects had higher total antioxidant capacity compared to hepatitis C (+) hemodialysis subjects (all p < 0.05/3). Total peroxide level and oxidative stress index was comparable between hemodialysis subjects with or without hepatitis C infection (p > 0.05/3).ConclusionOxidative stress is increased in both hepatitis C (+) and hepatitis C (-) hemodialysis subjects. However, hepatitis C infection seems to not cause any additional increase in oxidative stress in hemodialysis subjects and it may be partly due to protective effect of dialysis treatment on hepatitis C infection.

Highlights

Both uremia and hepatitis C infection is associated with increased oxidative stress
We evaluated the oxidative status in hepatitis C virus (HCV) (+) HD subjects, HCV (-) HD subjects and healthy controls via measurement of total antioxidant capacity (TAC) [19] and total peroxide level in plasma samples, and calculation of oxidative stress index (OSI) [20]
Dialysis duration was comparable between HD subjects with or without HCV infection (P > 0.05)

Summary

Introduction

Both uremia and hepatitis C infection is associated with increased oxidative stress. We aimed to find out whether hepatitis C infection has any impact on oxidative stress in hemodialysis subjects. Oxidative stress can be defined as an increase in oxidants and/or a decrease in antioxidant capacity [1], and is being increasingly associated with a wide spectrum of renal diseases [2,3]. Several prevalence studies of hepatitis C virus (HCV) infection have been undertaken in HD patients. HCV-related liver disease usually runs an indolent course in HD patients [13]. It has been shown that HCV infection itself is characterized by an increase in free radical formation manifested by increased hepatic and serum levels of products of lipid peroxidation [14,15]

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