Oxidative stress correction with metabolic preparations, new possibilities of antioxidant protection in primary glaucoma

I N Mikheytseva,V N Yelskiy

doi:10.24959/ubphj.16.47

Abstract

There were studied antioxidant action of water-soluble form of quercetin – corvitin and melatonin in rabbits with glaucoma model. It was shown intravenous injections of corvitin essentially decreased oxidative stress in animals with advanced stage of experimental glaucoma. Prophylactic-protective apply of melatonin on the basis of model induction in significant degree protected oxidative stress development.

Highlights

Today it is known that mechanisms of free radical damage and oxidative stress play an important role in the pathogenesis of primary glaucoma, contributing primarily formation of glaucomatous optic neuropathy [15, 22]
Our study of pro- and antioxidant status of animals with the induced glaucoma have confirmed our previous results [2] and found a high level of oxidative stress in animals of group glaucoma model (GM). It has been manifested by an increase in the content of secondary product of lipid peroxidation Malonic dialdehyde (MDA) by 103 %, and a decrease in antioxidant status, reflected in a reduction of 40 % total antioxidant activity of blood plasma (TAOA) in blood plasma (Table)
Comparing the severity of oxidative stress in the GMC and GM groups it has been revealed that under the influence of Corvitin high MDA levels have been decreased by 39.2 % and TAOA has been increased by 40.3 % in blood of rabbits with developed glaucoma

Summary

Introduction

Today it is known that mechanisms of free radical damage and oxidative stress play an important role in the pathogenesis of primary glaucoma, contributing primarily formation of glaucomatous optic neuropathy [15, 22]. According to some authors [17, 12] the formation of oxidative stress caused by unstable ocular blood flow is one of the main risk factors for glaucomatous optic neuropathy As it states in repeated mild reperfusion, as a consequence of unstable blood flow, a large amount of free radicals is formed. GMC group rabbits with the ocular and metabolic functions disorders has largely hindered severity of oxidative stress in them In this group MDA levels compared to the control was increased by 22 % and TAOA reduced by 16.1 %. Comparing the severity of oxidative stress in the GMC and GM groups it has been revealed that under the influence of Corvitin high MDA levels have been decreased by 39.2 % and TAOA has been increased by 40.3 % in blood of rabbits with developed glaucoma. When comparing these results with the untreated GM group, MDA levels has been lower by 44.1 % and TAOA – above by 33.5 % under the action of melatonin

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Methods

Conclusion