Abstract
BackgroundOxidative stress (OxS) has recently been linked with osteoporosis; however, we do not know the influence of OxS as an independent risk factor for this disease.MethodsWe conducted a case-control study in 94 subjects ≥60 years of age, 50 healthy and 44 with osteoporosis. We measured total antioxidant status, plasma lipid peroxides, antioxidant activity of superoxide dismutase and glutathione peroxidase (GPx), and calculated the SOD/GPx ratio. Bone mineral density was obtained at the peripheral DXA in calcaneus using a portable Norland Apollo Densitometer®. Osteoporosis was considered when subjects had a BMD of 2.5 standard deviations or more below the mean value for young adults.ResultsGPx antioxidant activity was significantly lower in the group of subjects with osteoporosis in comparison with the group of healthy subjects (p < 0.01); in addition, the SOD/GPx ratio was significantly higher in the group of individuals with osteoporosis (p < 0.05). In logistic regression analysis, we found OxS to be an independent risk factor for osteoporosis (odds ratio [OR] = 2.79; 95% confidence interval [95% CI] = 1.08–7.23; p = 0.034).ConclusionOur findings suggest that OxS is an independent risk factor for osteoporosis linked to increase of SOD/GPx ratio.
Highlights
Oxidative stress (OxS) has recently been linked with osteoporosis; we do not know the influence of OxS as an independent risk factor for this disease
Our findings suggest that OxS is an independent risk factor for osteoporosis linked to increase of superoxide dismutase (SOD)/glutathione peroxidase (GPx) ratio
Concerning OxS biological markers, we found that LPO did not show differences statistically significant
Summary
Oxidative stress (OxS) has recently been linked with osteoporosis; we do not know the influence of OxS as an independent risk factor for this disease. Oxidative stress (OxS) is a biochemical disequilibrium propitiated by excessive production of free radicals (FR) and reactive oxygen species (ROS), which provoke oxidative damage to biomolecules and which cannot be counteracted by antioxidative systems. This biochemical alteration has been linked with aging and more of 100 chronic-degenerative diseases, among which osteoporosis is found [1,2]. Epidemiologic studies on osteoporosis should consider OxS, in addition to risk factors linked with lifestyles, hormonal changes, and aging [3,4,5]. Arjmandi et al (2002) demonstrated that administration of vitamin E has a beneficial effect on bone quality in old rats [11]; the association between OxS and bone mineral density (BMD) in humans has scarcely been approached
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