Oxidative Stress and the Loss of Receptor Sensitivity in Aging

Abstract

In this “decade of the brain” it is important to note that the U.S population is becoming older, and all the attendant age-related central neuronal alterations as well as correlative behavioral changes will be showing increases as well. By the year 2050 fully 30% of the total population will be over 65 years of age and there is a high probability that they will be exhibiting the most common behavioral alterations occurring in aging (i.e., decrements in motor and certain types of memory functions). Specifically, alterations in motor function may include decreases in balance, muscle strength and coordination, while memory deficits appear to occur primarily in secondary memory systems and are reflected in the retrieval of newly acquired information. Indeed, these characterizations have been supported by a great deal of research both in animals and humans. It should be evident that in cases of severe deficits in memory (e.g., Alzheimer’s Disease, AD) or motor function (Parkinson’s Disease, PD) during aging and in age-related diseases hospitalization and/or custodial care would be a likely outcome. This means that unless some means is found to reduce these decrements in neuronal function the health care costs will be staggering, and today’s costs will pale by comparison.