Oxidative stress and neurological disorders: Therapeutic strategies and pharmacological intervention

Abstract

Oxidative stress plays a significant role in cerebral biochemical dysfunction, contributing to the increased sensitivity of the central nervous system to reactive oxygen species (ROS)-mediated injury. It is characterized by an imbalance between the production of ROS and the antioxidant capacity of the cell, which results in a variety of pathological disorders and diseases, including neurological conditions such as Parkinson’s disease, Alzheimer’s disease, schizophrenia, bipolar disorder, and anxiety. In this review, we delve into the role of oxidative stress in neurodegenerative disorders. We conducted a comprehensive search across various databases, including Google Scholar, ScienceDirect, and PubMed, with a focus on literature published within the past decade. Our search utilized terms such as “oxidative stress and neurological disorders,” “pharmacological interventions for neurological disorders,” “oxidative stress, free radicals, and neurological disorders,” and “free radicals and neurological disorders. Our aim was to elucidate the relationship between oxidative stress and neurological disorders, as well as to summarize available therapies and pharmacological interventions for these conditions.