Abstract
Malnutrition and increased free radicals generation are common findings with tuberculosis patients and these can impair their antioxidant capacity. The present study was carried out to estimate the levels of non-enzymatic antioxidants: albumin, vitamin C and E, selenium and lipid fractions in sixty–five (M = 29; F = 36) newly diagnosed (untreated) adult active tuberculosis (TB) patients and to compare them with the levels in fifty (M = 25; F = 25) apparently healthy tuberculosis free individuals of the same age group and location. Lipid fractions, MDA, albumin, vitamins C and E were estimated by standard spectrophotometric methods while selenium concentration was determined by atomic absorption spectrophotometric method. There was a significantly increased concentration of MDA (P < 0.001) in TB patients when compared with the control subjects and significantly reduced concentrations of albumin, vitamin C and E, selenium, total–cholesterol, LDL-cholesterol (P < 0.001in each case) and triglyceride (P < 0.01) were observed when the TB patients were compared with non TB infected individuals. The study showed that TB patients are predisposed to oxidative stress and reduced concentrations of lipid fractions. Highly nutritious diet fortified with antioxidants supplements is advocated for TB patients alongside chemotherapeutic management and their lipid fractions status should be monitored while managing the patients.
Highlights
Mycobacterium tuberculosis is considered as an etiologic agent of tuberculosis (TB) with the identifying feature of the organism been an acid –fast property (Nwanjo and Oze,2007)
The present study is on evaluation of lipid peroxidation product, non-enzymatic antioxidants and lipid profile in tuberculosis (TB) patients without history of smoking or HIV disease
The results showed higher lipid peroxidation products and significantly lower antioxidants potential in TB patients
Summary
Mycobacterium tuberculosis is considered as an etiologic agent of tuberculosis (TB) with the identifying feature of the organism been an acid –fast property (Nwanjo and Oze ,2007). Almost one third of the world’s population is infected with Mycobacterium tuberculosis and the majority of these individuals live in less developed countries (Swaminathan et al, 2008) It is commonly a disease of the lung where it forms a localized infection after inhalation. Recent research suggest that in pulmonaryTuberculosis there is increase in severalcirculating markers of free radical activity,indicating ongoing oxidative stress anddecrease in the antioxidant activity which maycontribute to development of lung functionabnormalities (Ragunath and Madhavi ,2006). These are important part of the host defense against the organism; enhanced reactive oxygen species (ROS) generation may promote tissue injury and inflammation. The present study was aimed at investigating the status of lipid peroxidation products (malondialdehyde), non-enzymatic antioxidants, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol in TB patients so as to provide information that will enhance success rate in treatment and management of patients with TB in our country
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