Abstract
<p>Reactive oxygen species (ROS) play a role in a numbered of degenerative conditions including psoriasis. Psoriasis is a chronic inflammatory disease who’s the etiopathogenesis is not yet completely understood, and therefore there is no standardized therapeutical approach. Flavonoids, recognized as potent antioxidants, are multifunctional molecules that can act as anti-inflammatory and antiproliferative agents through the modulation of multiple signaling pathways. The present study was designed to investigate the protective role of flavonoids [quercetin, chrysin, curcumin or Epigallocatechin 3-gallate (EGCG)] against n-Hexyl salicylate (HXS)-induced oxidative stress and inflammation in skin. Anti-oxidative and anti-inflammatory effect of flavonoids is quantified by histopathological assessment of skin, measuring the levels of lipid peroxidation and glutathione (GSH) in the skin, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, and hematological and biochemical parameters.</p><p>Topically applied of n-Hexyl salicylate caused significant increase in lipid peroxidation and decrease in GSH, which is accompanied by an increase<strong> </strong><em>total number of inflammatory cells in skin and peritoneal cavity, functional activity of macrophages, and enzymatic activity of ALP and AST.</em> In contrast, topically applied 5 % preparation of flavonoids (quercetin, chrysin, curcumin or EGCG) with HXS effectively prevented these alterations and maintained the antioxidant status.</p><p>The results suggest that flavonoid preparations can serve as a potent antioxidant and anti-inflammatory agents in psoriatic-like skin lesions, without toxic effects.</p>
Highlights
The skin is an external organ that covers the entire body surface
Cellular infiltration represents an important feature in skin inflammation, and neutrophils are the predominant type of cells that infiltrate the area
It seems that Reactive oxygen species (ROS) that are produced by lipid peroxidation may activate phospholipase A2 and cause peroxidation of many mediators by arachidonic acid which metabolized to MDA [21, 22]
Summary
The skin is an external organ that covers the entire body surface. It is responsible for the communication between an organism and the environment and is constantly subjected to exogenous stimuli. The skin is a biological interface with the environment, and is frequently and directly exposed to prooxidative stimuli including chemical oxidants, ultraviolet and visible irradiation, which are known to promote the generation of ROSs and lipid peroxides [2]. Initiation of the defense response is characterized by the infiltration of neutrophils and the release of several proinflammatory mediators, which starts the inflammatory process. If this inflammatory response is not appropriately regulated, an inflammatory skin disease can be triggered [3]. The most common inflammatory skin disorders include atopic dermatitis and psoriasis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
