Abstract
The purpose of this study was to elucidate the mechanism underlying toxicity in the livers of male and female rats after treatment with 1-tetradecyl-3-methylimidazolium tetrafluoroborate ([C14mim]BF4, 0 [control], 12.5, 25, or 50mg/kg) for 90days. The results showed that [C14mim]BF4 exposure led to a high level of ROS and MDA in rat livers and the lower expression of Nrf2 and its downstream related antioxidant proteins. In addition, the expression of NF-κB p65 and the levels of inflammatory cytokines were upregulated in exposure groups rats' liver. After 30days of cessation of exposure, the liver injury of rats in the 50mg/kg exposure group was alleviated, and the above indicators were improved to varying degrees. The paper shows that [C14mim]BF4 could damage rat liver through oxidative stress and inflammatory pathway.
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