Abstract
Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. <i>Methodology:</i> A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. <i>Result:</i> The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. <i>Conclusion:</i> These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
Highlights
Skin problems are generally the most common diseases seen in primary care setting all over the globe and its prevalence ranges from 20-50% in developing countries
The presented study concluded that oxidative stress in psoriatic patients indicated by increased Total oxidant capacity (TOC) as well as oxidative stress index (OSI) and decreased Total Antioxidant Capacity (TAC) levels when compared to healthy controls
The study found worsened oxidant and antioxidant status according to the severity and duration of disease which may presumably be the causative factor in the pathogenesis of psoriasis
Summary
Skin problems are generally the most common diseases seen in primary care setting all over the globe and its prevalence ranges from 20-50% in developing countries. Psoriasis is one amongst these notorious auto-immune disorder having deep psychological and social impacts [2]. Psoriasis is non- contagious skin disease affecting both sexes and can occur at any age, it most commonly appears for the first time between the ages of 15 and 25 years [3, 4]. The population prevalence of psoriasis has been reported to range from 2% to 3%. Around 150,000 new cases of psoriasis are reported annually. Studies in developed countries have reported higher prevalence rates of on average about 4.6% [5]
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