Oxidative Stress and Hepatic Monooxygenase Function in Coronary Heart Disease Patients with Multiple Organ Dysfunction

Abstract

Objective: to study hepatic monooxygenase function (HMF) in cardiosurgical patients with multiple organ dysfunction (MOD). Subjects and methods. Twenty-six patients with MOD signs after operations on the open heart and 29 patients with an uncomplicated postoperative period were examined. The severity of HMF was evaluated by the SOFA scale and HMF was assessed by the pharmacokinetics of antipyrine (AP). Results. Within the first 24 hours after surgery, there were significant signs of MOD and a nearly two-fold reduction in HMF in the study group. A less significant depression of HMF was observed in the control group. On postoperative days 3—4, the total index of MOD noticeably decreased in the study group. There was an increase in HMF in both groups. On days 10—12 after surgery, the severity of MOD distinctly increased in the study group, which was accompanied by a considerable reduction in HMF. In this period, in the control group HMF corresponded to the baseline values. Correlation analysis revealed a direct relationship of the total index of MOD severity with AP Tj/2 and a negative correlation of the number of organ lesions with AP clearance. Conclusion. In cardiosurgical patients, MOD causes a more significant and longer diminution of HMF than in those with an uncomplicated postoperative period. The rate of HMF reduction is directly related to the number of organ lesions and the total index of MOD severity. Key words: hepatic monooxygenase function, multiple organ dysfunction, antipyrine, cardiosurgical patients.