Abstract
BackgroundOxidative stress is implicated in the pathogenesis of migraine, but no published studies have examined both oxidative stress levels and oxidative DNA damage on the same patient group.MethodsIn this study, total oxidant status (TOS); total antioxidant status (TAS); oxidative stress index (OSI); and 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is an indicator of oxidative DNA damage, were measured in the plasma samples of 50 prophylactic unmediated migraineurs (11 with aura and 39 without aura) and 30 matched healthy volunteers.ResultsNo significant differences in TAS, TOS, and OSI values were observed between patients and controls. However, plasma 8-OHdG levels were found to be significantly higher in migraine patients than in the control group (p = 0.001); this increase in plasma 8-OHdG levels was more prominent in cases with migraine without aura than with aura (p = 0.001). Our results suggested an evidence of oxidative stress-related DNA damage in migraine.ConclusionDNA damage reflected by plasma 8-OHdG did not studied in migraine before. Therefore, further research on oxidative stress-related DNA damage and the extent of its clinical manifestations in migraine may provide additional data to our current knowledge.
Highlights
Oxidative stress is implicated in the pathogenesis of migraine, but no published studies have examined both oxidative stress levels and oxidative DNA damage on the same patient group
We aimed to evaluate the plasma total oxidant status (TOS); plasma total antioxidant status (TAS); oxidative stress index (OSI); and 8-hydroxy-2′deoxyguanosine (8-OHdG), which is an indicator of oxidative DNA damage, in patients with migraine in the interictal phase, taking into account the different subgroups of patients with and without aura
This study examined 50 consecutive patients aged 18–45 years, who were diagnosed to have migraine and were not on prophylactic treatment for at least 3 months and for at least 72 h symtomathic drugfree period before obtaining blood samples in the interictal phase
Summary
Oxidative stress is implicated in the pathogenesis of migraine, but no published studies have examined both oxidative stress levels and oxidative DNA damage on the same patient group. Among the DNA constituents, guanine has the lowest ionization potential; it is highly susceptible to the actions of free radicals. The oxidation product, 8-hydroxy-2′-deoxyguanosine (8-OHdG) generated by the hydroxylation of guanine at the C8 position is one of the most common biomarkers used to detect oxidative DNA base damage induced by ROS [8]
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