Abstract
Concurrent with the misbalance of oxidizing agents and antioxidants, high blood pressure is a major physical burden condition in the current scenario. Tumor necrosis factor-α (TNF-α) plays a vital role in the pathogenesis of hypertension. Tumor necrosis factor-α, inhibitor improves clinical symptoms however their outcome on high blood pressure has not been investigated. We investigated the inflammatory marker TNF-α, malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) in hypertensive patients. We measured randomly blood pressure using an ambulatory observe in hypertensive patients, measured systolic BP X 140 mmHg and/or diastolic BP X 90 mmHg were considered hypertensive. Total 60 cases were considered in the study that involves 30 hypertensive patients and 30 normal control. Measurements of serum concentrations of TNF-α, MDA, FRAP in hypertension patients was done in both the groups. Serum TNF-α was found to be remarkably increased in study subjects as compared to normal group (r=0.32, p<0.0001*). Serum MDA was also raised in hypertensive as compared to control (r=0.99**, p<0.0001*). While Serum FRAP was found to be decreased in hypertensive group in comparison to healthy control (r=0.23, p<0.0001*). It is concluded that high blood pressure leads to generation of oxidative stress with remarkable elevation of TNF-α and malondialdehyde levels. While reduced FRAP indicates its probable role in lipid peroxidation and in the pathogenesis of hypertension.
Highlights
Hypertension is a main health problem in developed as well as developing countries with a common end result of elevated blood pressure (BP)
Oxidative stress is the state of imbalance between the reactive oxygen species (ROS) and the ability of the biological system to detoxify readily the reactive intermediates that improves vascular oxidative stress which could be consider to the pathogenesis of high blood pressure – a major jeopardy factor for heart disease mortality [2, 3]
Total 60 samples were considered in the study out of which 30 were hypertension patients and 30 were normal individuals
Summary
Hypertension is a main health problem in developed as well as developing countries with a common end result of elevated blood pressure (BP). High blood pressure (essential hypertension) is defined as systolic pressure >140 and/or diastolic pressure >90. Oxidative stress is the state of imbalance between the ROS and the ability of the biological system to detoxify readily the reactive intermediates that improves vascular oxidative stress which could be consider to the pathogenesis of high blood pressure – a major jeopardy factor for heart disease mortality [2, 3]. Oxidative stress occurs while an imbalance between the generation of ROS, the antioxidant protection systems so that the latter become overwhelmed [4, 5]. High blood pressure ROS may raise due to a decrease in the activity of antioxidant enzymes [6]. The relationship between high blood pressure, oxidative stress and antioxidants is complex and inadequately understood. Human and animal studies have demonstrated that HT is accompanied by increase in oxidative stress
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