Abstract
Objectives: Oxidative stress is an important pathophysiological mechanism in non-alcoholic steatohepatitis (NASH). We aimed to evaluate serum xanthine oxidase (XO) (as a generator of reactive oxygen species), superoxide dismutase (SOD), glutathione peroxidase (GSH Px), paraoxonase (PON1) activities, nitric oxide (NO) and thiol levels in patients with NASH. Design and methods: A total of 35 patients with NASH and 31 age-and-gender-matched healthy subjects were enrolled in the study as control group. Serum levels of XO, NO, SOD, GSH Px, PON1 and thiol were determined by spectrophotometric methods. Results: Serum XO activities were higher in the patients with NASH than the controls ( p < 0.001). Serum NO levels, SOD, GSH Px, PON1 activities and thiol levels were lower in the patients with NASH than the controls ( p < 0.031, p < 0.019, p < 0.001, p < 0.001, p < 0.001, respectively). Conclusions: Increased oxidative stress in patients with NASH may result in a pro-oxidation environment, which in turn could result in decreased antioxidant enzyme activities and NO levels. Therefore effective antioxidant therapy to inhibit oxidative stress is necessary and agents to increase antioxidant enzyme may be a therapeutic option in NASH.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.