Abstract
BackgroundTo investigate the relationship between blood adipokine level and oxidative stress in diabetic patients with hyperglycemic crises before and after treatment.MethodsWe measured superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), and levels of 8-iso-prostaglandin F2α (8-iso-PGF2α), adiponectin, leptin, and resistin in 63 diabetic patients with hyperglycemic crises.ResultsPrior to treatment, patients with hyperglycemic crises had significantly lower serum SOD activity, TAC, and adiponectin and leptin levels, and higher serum levels of MDA, 8-iso-PGF2α, and resistin compared with the healthy control individuals (all at P < 0.05). After treatment, SOD, TAC, adiponectin, and leptin levels increased significantly, while MDA, 8-iso-PGF2α, and resistin levels decreased significantly (all at P < 0.05) in the patients.ConclusionsDiabetic patients with hyperglycemic crises have increased oxidative stress, which is associated with serum adipokine abnormalities; improved oxidative stress after treatment suggests that oxidative stress may serve as target and/or indicator for the treatment of hyperglycemic crises.
Highlights
Hyperglycemic crisis is a common acute complication of diabetes in patients with hyperglycemia [1, 2]
Blood glucose was estimated with the glucose oxidase method; HbA1c was detected with high performance liquid chromatography; blood leukocytes were counted using a 5-part differential hematology analyzer
The blood leukocyte counts in the diabetic patients were significantly lower than before treatment (P < 0.05), and were not significantly different from the counts in the control group
Summary
Hyperglycemic crisis is a common acute complication of diabetes in patients with hyperglycemia [1, 2]. Basic and clinical studies have shown that hyperglycemic crises aggravate inflammation and increase the risks of myocardial infarction, heart failure, and cardiogenic shock. Acute hyperglycemia is considered a risk factor for myocardial infarction in patients with type 2 diabetes [1, 2]. Adiponectin has anti-diabetic properties because it increases insulin sensitivity by reducing inflammation and oxidative stress [9, Li and Shen D iabetol Metab Syndr (2019) 11:13. To investigate the relationship between blood adipokine level and oxidative stress in diabetic patients with hyperglycemic crises before and after treatment
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