Oxidative stress – an important marker in Mild Cognitive Impairment and Alzheimer disease

Abstract

Event Abstract Back to Event Oxidative stress – an important marker in Mild Cognitive Impairment and Alzheimer disease Manuela Padurariu1*, Cristinel Stefanescu1, Alin Ciobica2 and Roxana Branzei3 1 Gr.T.Popa University, Romania 2 Romanian Academy, Romania 3 Psychiatry Hospital Iasi, Romania Mild cognitive impairment (MCI) is a transitional stage between normal cognitive aging and mild dementia or clinically probable Alzheimer's disease (AD). There is a great interest in the relationship between MCI and the progression to Alzheimer's disease (AD). Several studies demonstrated the importance of oxidative stress in the pathogenesis of AD. The aim of this study was to determine the oxidative stress status in MCI and AD patients.The patients were selected using Petersen criteria for MCI and NINCDS ADRDA criteria for AD. The cognitive performance was assessed using MMSE (Mini Mental State Examination), ADAS-cog (Alzheimer's Disease Assessment Scale- cognitive subscale), Clock Drawing Test and Verbal Fluency Test. We assessed the levels of some enzymatic antioxidant defences like superoxid dismutase (SOD) and glutathione peroxidase (GPX), as well as lipid oxidation makers like MDA (malondialdehyde), using chemiluminometric and spectrophotometric methods. The results were compared to an aged-matched control group. Alterations in the activity of the antioxidant enzymes (SOD and GPX) were found in MCI and AD peripheral blood compared to age-matched controls. Also, MDA levels were significantly increased in the AD and MCI patients, comparative with the control group. Moreover, in MCI patients, cognitive function positively correlates with antioxidant levels. These results support the hypothesis that oxidative damage is an important event in the pathogenesis of neurodegenerative diseases. Also, it seems that some peripheral markers of oxidative stress appear in MCI with a similar pattern to that observed in AD, which suggest that oxidative stress might represent a signal of the AD pathology. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Padurariu M, Stefanescu C, Ciobica A and Branzei R (2009). Oxidative stress – an important marker in Mild Cognitive Impairment and Alzheimer disease. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.250 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Jun 2009; Published Online: 12 Jun 2009. * Correspondence: Manuela Padurariu, Gr.T.Popa University, Iasi, Romania, manuelapadurariu@yahoo.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Manuela Padurariu Cristinel Stefanescu Alin Ciobica Roxana Branzei Google Manuela Padurariu Cristinel Stefanescu Alin Ciobica Roxana Branzei Google Scholar Manuela Padurariu Cristinel Stefanescu Alin Ciobica Roxana Branzei PubMed Manuela Padurariu Cristinel Stefanescu Alin Ciobica Roxana Branzei Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.