Abstract
Introduction:Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development.Materials and methods:The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient’s serums.Results:According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development.Conclusions:OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.
Highlights
Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children
total antioxidant status (TAS) and oxidative stress index (OSI) as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition
Further investigations are needed to evaluate whether TAS, Total oxidant status (TOS) and OSI could be used to monitor disease severity in children with UTI
Summary
Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. Oxidative stress as a state of imbalance between oxidant and antioxidant processes of the human body may be both the cause and the consequence of many diseases Due to this fact, the determination of oxidative stress, as well as the capacity of the antioxidant defence may be important for improving the health of individuals and of the general population. Polymorphonuclear leukocytes, a major limiting factor for bacterial growth in the urinary tract, are responsible for the development of renal tissue damage as well [4].
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