Abstract
AbstractA facile, metal‐free protocol has been developed for the remote trifluoromethylation of 8‐aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8‐aminoquinolineamides reacted with an inexpensive and commercially available CF3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.
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