Abstract
The spiroketal moiety is an important substructure within many biological natural products. One method to access them is via the oxidative cyclisation of a pendant hydroxyl group on to a pre‐formed pyran. However applications of this methodology have been severely limited by requiring the use of toxic and powerful oxidants, such as lead (IV) tetraacetate or mercuric oxide. Herein we report a novel and high yielding photochemical route to prepare complex spiroketals using a photochemical oxidative approach with mild and non‐toxic reagents and demonstrate the methodology to the synthesis of a number of insect pheromones.
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