Abstract
The stereoselective intramolecular dearomatizing spirocyclization of indoles via oxidative N-heterocyclic carbene (NHC) catalysis to afford indolenines bearing an all-carbon quaternary center at the 3-position is reported. The reaction proceeds via the intramolecular nucleophilic addition of the indole to an in situ generated α,β-unsaturated acyl azolium. The cyclized indolenine bearing an acyl azolium functionality is trapped by a suitable external nucleophile that does not efficiently react with the α,β-unsaturated acyl azolium via direct acylation.
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