OXIDATIVE MODIFICATIONS OF LIPOPROTEINS IN PATIENTS WITH VIBRATION DISEASE AND METABOLIC DISORDERS

Abstract

Introduction: Diabetes mellitus (DM) and metabolic syndrome (MS) are characterized by development of atherosclerosis and cardiovascular pathology. Vibration disease (VD) affects oxidative metabolism leading to the development of microangiopathies. However, the evidence on the combined effect of VD and DM or MS on oxidative modification of lipids remains limited. Aim: To study oxidative modification of lipoproteins in individuals with vibrationa disease and metabolic disorders. Metods: In total, 59 patients with VD (group I), 73 people with VD combined with MS (group II) and 35 people with VD and type 2 diabetes (group III) took part in the study. We assessed concentrations of total cholesterol, low density lipoproteins (LDL), oxidized low density lipoproteins (oxLDL), antibodies to oxLDL and thiol status. Results: Serum levels of total cholesterol, oxLDL and antibodies to oxLDL in all groups exceeded the reference values. The proportion of people with a high content of oxLDL varied between 61 % to 72 %. Increased levels of antibodies to oxLDL were observed in 63 % - 85 % of patients in all groups. The concentration of LDL cholesterol was the highest in group II: 3,6 (3,2-4,2) mM/l. Concentrations of oxLDL correlated with the levels of total cholesterol and LDL cholesterol. Lower thiol concentrations were found in 57 % of cases in group II). Conclusion: Our results suggest that individuals with VD have hypercholesterinemia, increased oxidative lipid metabolism and increased production of antibodies to oxLDL independently of metabolic disorders Patients with VD and type 2 diabetes may have decrease antioxidant defense.