Abstract
Abstract—Ozone-photodynamic effects on tumor growth rate and oxidative modification of proteins in rat tissues were studied using a model of PA kidney carcinoma. It was shown that the developed experimental therapeutic method based on the joint parenteral intraperitoneal administration of an ozonated saline solution with a concentration of ozone in the ozone–oxygen mixture of 400 μg/L and a 0.3% solution of the Photosens photosensitizer intratumorally with the local action of light with a wavelength of 660 ± 10 nm for 10 min reduced the intensity of tumor growth. Normalization of the prooxidant/antioxidant balance in experimental animals was observed upon combined use of ozonated saline solution and photodynamic therapy.
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