Abstract
The object of this study was to determine whether skeletal muscle adjusts its oxidative metabolism in response to compensatory hypertrophy. We therefore, measured the production of 14CO 2 from glucose-6- 14C and β-hydroxybutyrate-3- 14C by homogenates of rat plantaris and soleus muscles undergoing compensatory hypertrophy produced by elimination of synergists. There was a decrease in substrate oxidation by hypertrophic muscles. These results are in contrast to the increased oxidative capacity observed in skeletal muscle following endurance training.
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