Abstract
The pleural fluid was aspirated from the tuberculous patients both untreated and under treatment with three months anti-tuberculosis therapy. The amount of malondialdehyde, lactate dehydrogenase, and total protein content in pleural fluid of untreated tuberculous patients were found to be significantly higher when compared with under treatment group. The pleural fluid total antioxidant levels were significantly lower in untreated cases in comparison to under treatment. Decrease in the total antioxidant status was more pronounced in untreated cases, established that antioxidants were nearly completely utilized to scavenge the free radicals. Our findings further support the importance of antioxidants in the treatment of tuberculous patient.
Highlights
Mycobacterium can induce reactive oxygen species production by activating phagocytes (May and Spagnuolo, 1987; Attwood et al, 1996) and an important part of the host defense against mycobacteria, enhanced reactive oxygen species generation may promote tissue injury and inflammation
Lipid peroxidation product and malondialdehyde level estimated in the pleural fluid of tuberculous patients (Table I) was significantly decreased (p
In tuberculous patients based on treatment regimen, the pleural fluid lactate dehydrogenase levels were decreased significantly (p
Summary
Mycobacterium can induce reactive oxygen species production by activating phagocytes (May and Spagnuolo, 1987; Attwood et al, 1996) and an important part of the host defense against mycobacteria, enhanced reactive oxygen species generation may promote tissue injury and inflammation. This further contributes to immunosuppression (Jack et al, 1994; Grimble, 1994). Severe oxidative stress has been reported in tuberculosis patients because of malnutrition and poor immunity (Reddy et al, 2004). The prospective study was under taken to evaluate the role of oxidative stress in pleural fluid of tuberculosis patients
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