Abstract
Abstract1. Development of the endoplasmic reticulum and its drug-oxidizing enzyme system was studied in perinatal rabbit liver and placenta from the 20th day of gestation to the 14th day of life.2. The components of the microsomal drug-oxidizing electron transport chain and the drug-oxidizing capacity are absent, or present at negligible levels, in prenatal rabbit liver. A marked increase of the activities takes place at birth and during the first 2 weeks of life. Adult levels are not attained by the 14th day of life.3. Rough surfaced endoplasmic reticulum in the form of cisternae was observed on the 20th day of gestation in the foetal rabbit liver. Prenatally, the endoplasmic reticulum was mainly rough surfaced, whereas the smooth surfaced reticulum appeared after birth.4. Our findings show species difference in the development of the drug-oxidizing enzyme system between man and animals investigated, since human foetal liver contains the drug-oxidizing enzyme system.
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