Oxidative decarboxylation of arylacetic acids in water: One-pot transition-metal-free synthesis of aldehydes and ketones

Trimbak B. Mete,Ramakrishna G. Bhat,Tushar M. Khopade

doi:10.1016/j.tetlet.2017.06.013

Oxidative decarboxylation of arylacetic acids in water: One-pot transition-metal-free synthesis of aldehydes and ketones

Trimbak B. Mete, Ramakrishna G. Bhat + Show 1 more

https://doi.org/10.1016/j.tetlet.2017.06.013

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Journal: Tetrahedron Letters	Publication Date: Jun 14, 2017
Citations: 27

Affiliation: Indian Institute of Science Education and Research Pune

#Synthesis Of Aldehydes #Synthesis Of Aromatic Aldehydes + Show 8 more

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Abstract

Abstract One-pot transition-metal-free synthesis of aromatic aldehydes and ketones via oxidative decarboxylation of arylacetic acids in water is developed. Protocol relies on the direct decarboxylation of sp3-hybridized carbon in water without any over oxidation into carboxylic acids with minimal waste. Reaction mechanism is investigated and application of this protocol is demonstrated on a gram scale .

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