Oxidative decar☐ylation of α-amino acids: A mild and efficient method for the generation of N-acyliminium ions

Abstract

The oxidative decar☐ylation of α-amino acids using the system (diacetoxyiodo)benzene or iodosylbenzene and iodine proceeded smoothly at room temperature. The intermediacy of an N-acyliminium cation has been demonstrated through intermolecular and intramolecular trapping with nucleophiles.