Oxidative coupling of bromo- and iodo-ferulic acid derivatives: synthesis of (±)-veraguensin

Abstract

The phenolic coupling of halogen-containing ferulic acid and methyl ester derivatives was examined with particular reference to the synthesis of lignans of the aryltetralin and tetrahydrofuran classes. (±)-Isolariciresinol dimethyl ether ( 18) and (±)-veraguensin ( 27) have been synthesized.