Abstract
Iodine is an effective promoter for the carbonylation of primary and secondary amines to ureas using palladium acetate as the catalyst and a base (e.g. K2CO3) in acetonitrile (3 h at 95 °C and 2.7 atm). Oxamides are formed in excellent yields when secondary amines are carbonylated in the presence of iodide ion and oxygen, while primary amines give ureas as the principal product at 95 °C, and oxamide at room temperature. Keywords: oxamides, ureas, double carbonylation, amines.
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