Oxidative C–O coupling as a new idea in the ‘click-like chemistry’: malonyl peroxides for the conjugation of two molecules

Vera A Vil’,Evgenii S Gorlov,Oleg V Bityukov,Igor B Krylov,Gennady I Nikishin,Kasimir K Pivnitsky,Alexander O Terent’Ev

doi:10.1016/j.mencom.2019.03.003

Oxidative C–O coupling as a new idea in the ‘click-like chemistry’: malonyl peroxides for the conjugation of two molecules

Vera A Vil’, Evgenii S Gorlov + Show 5 more

https://doi.org/10.1016/j.mencom.2019.03.003

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Journal: Mendeleev Communications	Publication Date: Mar 1, 2019
Citations: 1

Affiliation: N.D. Zelinsky Institute of Organic Chemistry, D. Mendeleyev University of Chemical Technology of Russia

#Malonyl Peroxides #Barbituric Acid + Show 4 more

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Abstract

Malonyl peroxides were used for the one-pot construction of hybrid structures by conjugation of heterocycle (3H-pyrazol-3-one, isoxazol-5(2H)-one, pyrazolidine-3,5-dione, or barbituric acid) and amine or alcohol. The first stage represents oxidative C–O coupling with liberation of the carboxyl group which is functionalized at the second stage thus affording ‘clicklike’ products with malonic linker.

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