Abstract
Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). The prospective study included a group of 71 children during a period of 2 years. In all children, laboratory tests were performed and intima-media complex in the carotid artery was measured (IMC). Low values of OS were more frequent in children with IBD than in the FGID group. The average concentration of oxidized lipoprotein with average density (oxLDL) was lower in patients with IBD. Among patients with IBD, higher concentrations of oxLDL were recorded in patients with longer-duration disease and with higher concentrations of total cholesterol. In the IBD group, more often, higher concentrations of anti-oxLDL were recorded among patients with longer-duration disease. The obtained results did not support the hypothesis of total antioxidant capacity depletion and greater overall OS in patients with IBD. Patients with IBD with a longer duration of the disease have higher concentrations of oxLDL and anti-oxLDL.
Highlights
Inflammatory bowel disease (IBD), ulcerative colitis, and Crohn’s disease are chronic gastrointestinal diseases with unclear etiology
Low values of oxidative stress were more frequent in children with UC (N = 8; 22.2%) and CD (N = 5; 14.3%), than in the functional gastrointestinal disorders (FGID) group (N = 2; 6.9%)
Kocaman et al proved that both dependent and independent endothelial dilation of blood vessels depend on the illness severity and are more severe in patients with a severe or moderate form of colitis ulcerosa and the endothelial dysfunction is associated with parenteral complications dependent of the intestinal disease activity [4]
Summary
Inflammatory bowel disease (IBD), ulcerative colitis, and Crohn’s disease are chronic gastrointestinal diseases with unclear etiology. Their clinical presentation is dominated by chronic inflammatory process affecting the gastrointestinal tract and with extraintestinal manifestation in 25–35% of patients. The etiopathogenesis of these diseases is multifactorial. Oxidative stress has been implicated in the disease pathogenesis and/or development [2]. Insufficient antioxidant protection or excessive production of ROS generates a condition known as oxidative stress. The term “endothelial dysfunction” refers to reduced production or availability of the main relaxing factor—nitric oxide (NO)—and increase in the shrinking factors, including endothelin-1, angiotensins, and oxidants, Boys (N (%)) Age (years) Duration of disease (months) BMI (kg/m2) BMI (Z-score)
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