Abstract
Oxidative and anti-oxidative effect of anesthesia compounds (ketamine and xylazine) on the rabbit blood sample using electrochemical method
Highlights
Initial studies using electrochemical analysis to finding the oxidation – reduction properties have been made for different pharmaceutical materials and their effects on the blood composition [1,2,3,4,5].Xylazine may be inhaled or the drug will be used as a veterinary anesthetic
All three electrodes immersed in the blood sample of the cyclic voltammetry (CV) cell, and these three electrodes connected to the potentiostat and with personal computer to determine the voltammogram of the results as shown in Figure 3 [14]
From the results the effect of using different concentrations of both ketamine (KN) and xylazine (XZ) as well as both of them was studied in the rabbit blood samples to identify the reaction of oxidation – reduction current peaks
Summary
Xylazine may be inhaled or the drug will be used as a veterinary anesthetic. The recommended dose varies between species given intravenously, intramuscularly, subcutaneously or orally, either by itself or in combination with other anesthetics, such as ketamine which is a drug primarily used to initiate and maintain anesthesia [6,7]. The electrochemical behavior of ketamine is studied through the use of cyclic voltammetry (CV) in global buffers with a pH ranging from 2.0-12.0. Kinetic parameters, such as transport coefficients, propagation coefficients, and heterogeneous constant values of the forward rate were evaluated using these techniques. The CV was used to estimate ketamine in selected drug combinations [8]
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