Oxidative amidation of aldehydes with amine in a mixture of choline chloride and aluminium nitrate as oxidant and solvent

Abstract

Amides can be synthesized directly from aldehydes and amines in high yield using a catalyst. The reaction, involving aldehydes and amines, was carried out in a mixture containing choline chloride and aluminum nitrate as a solvent and a catalyst to produce amides. Such catalyst was far more effective compared to other current catalytic systems. The reaction consistently gave exceptionally remarkable results for various aldehyde and amine derivatives under the specified reaction conditions. This method offers several advantages, including easy separation of products, efficiency, environmentally safe nature of the solvent, and elimination of expensive and hazardous catalysts. These features emphasize the importance of such groundbreaking reactions. Due to the significant polar characteristics and insolubility of the resulting products in water, the addition of water into the reaction mixture facilitates the easy separation of the products from the reaction medium. Consequently, this particular ionic liquid method provides a simple route for the synthesis of these important compounds.