Abstract
The important acetylcholinesterase inhibitor, physostigmine, has been studied at carbon electrodes across a range of pH's. The redox chemistry is very complex, resulting in a number of pH dependent products which have been examined by liquid chromatography and optical spectroscopy. Bulk electrolysis ( n-values) cyclic voltammetry, and chronoamperometry were used to ascertain the rate and mechanisms of the principal pathways. Several products have been identified while others remain uncharacterized. Oxidation of physostigmine in the presence of glutathione was undertaken to simulate liver metabolism of the drug. A number of reactions take place, including the formation of the expected nucleophilic addition product with the tripeptide.
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