Abstract

Abstract Oxidation of thymine and 1,3-dimethylthymine with hydrogen peroxide in hydrochloric acid (pH 1.0–2.2) at 35–38 °C gave the corresponding trans-5-chloro-6-hydroperoxy-5,6-dihydrothymines. The formation of the hydroperoxythymines was dependent on pH of the aqueous solutions. Reaction of the hydroperoxythymine with amino acids and nucleic acids related compounds in deuterium oxide was investigated by NMR spectroscopy.

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