Abstract
Quinolones and isoquinolones are of particular importance to pharmaceutical industry due to their diverse biological activities. However, their synthetic protocols were limited by high toxicity, high energy consumption, poor functional group tolerance and noble metal catalyst. This study concerns the development of a series of TEMPO@PCN-222 (TEMPO: 2,2,6,6-tetramethylpiperidinyl-1-oxy; PCN: porous coordination network) composite photocatalysts by coordinating different amount of 4-carboxy-TEMPO with the secondary building units of PCN-222. Upon visible-light irradiation, photogenerated holes in the highest occupied molecular orbital of PCN-222 can smoothly transfer to TEMPO, which can significantly boost the photosynthesis of bioactive (iso)quinolones from readily available N-alkyl(iso)quinolinium salts. TEMPO@PCN-222 exhibits an outstanding catalytic stability and substrate tolerance with a 1-methyl-2-quinolinone yield of 86.7 %, over four times that with PCN-222 (21.4 %). This work provides a new route to construct composite photocatalysts from abundant starting materials for efficient photosynthesis of high value-added chemicals.
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