Abstract
Microsomes isolated from excised shoots of 3-day-old, dark-grown, corn (Zea mays L., Pioneer Hybrid 3245) seedlings metabolized two endogenous substrates (cinnamic acid and lauric acid), one insecticide (diazinon), and six herbicides (metolachlor, bentazon, CGA-152005, triasulfuron, primisulfuron, and nicosulfuron). Pretreatment of the seed with the safener naphthalic anhydride resulted in enhanced metabolism of all substrates except cinnamic acid. Metabolism required NADPH and was affected by several cytochrome P450 monooxygenase inhibitors (tetcyclacis, piperonyl butoxide, 1-aminobenzolriazole, SKF-525A, and tridiphane). The inhibitors differentially affected metabolism of the substrates. Tetcyclacis and piperonyl butoxide strongly inhibited the metabolism of all substrates except cinnamic acid. Microsomal oxidations from both unsafened and safener-treated tissue responded similarly to the inhibitors. The differential inhibitory responses suggest that metabolism may involve several monooxygenase isoforms.
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