Oxidation of Halides, Ethers, Acetals, Sulphides, and Some Nitrogen Containing Compounds

Abstract

The direct conversion of alkyl halides into the corresponding carbonyl compounds, despite its potential interest for organic synthesis, is seldomly referred to in the literature. Only few examples of the oxidation of benzylic halides with aqueous acidic chromic acid or with aqueous sodium dichromate and alkali hydroxides [1] under rather drastic conditions have been reported. A preparatively useful example is the oxidation of α-chlorohydrindene to a-hydrindanone in 50–60% yield by means of chromic acid in aqueous acetic acid at 40 °C [2]: Open image in new window