Oxidation of a Anticholinergic Drug Atropine Sulfate Monohydrate by Alkaline Copper(III) Periodate Complex: A Kinetic and Mechanistic Study

Abstract

AbstractThe oxidation of a anticholinergic drug, Atropine sulfate monohydrate (ASM) by diperiodatocuprate(III) (DPC) has been investigated spectrophotometrically in aqueous alkaline medium at a constant ionic strength of 0.50 mol dm-3. The reaction between diperiodatocuprate(III) and atropine sulfate exhibits1:2stoichiometry (atropine sulfate: diperiodatocuprate(III)). The main oxidation products were identified and confirmed by spectral studies including IR,1H NMR and GC-MS. A suitable mechanism is proposed. The order with respect to diperiodatocuprate(III) concentration was unity, while the order with respect to atropine sulfate concentration was less than unity over the concentration range studied. The rates increased with an increase in alkali concentration and decreased with an increase in periodate concentration. The activation parameters with respect to slow step of the mechanism were calculated and the thermodynamic quantities we are also determined. Kinetic experiments suggest that [Cu(OH)2(H3IO6)]-is the reactive species of copper(III).