Abstract
Multiple biological consequences of oxidative stress are known to contribute to aging and aging-related pathologies. It was recently shown that (carboxyalkyl)pyrroles (CAPs), the end products of phospholipid oxidation serve as a novel class of endogenous ligands for Toll-like receptors (TLRs) and promote the process of angiogenesis. In this review, we discuss implications of these findings in the context of age-related pathologies, including tumorigenesis. Accumulation of oxidation products in tissues of aging organisms might create conditions for uncontrolled pathological angiogenesis as seen in patients with age related macular degeneration. CAPs and their receptors, TLRs might also promote the progression of atherosclerotic lesions. Importantly, besides their role in a number of pathologies, oxidative products of phospholipids contribute to tissue repair processes thereby antagonizing the destructive effects of oxidation.
Highlights
ΔAbstract: Multiple biological consequences of oxidative stress are known to contribute to aging and aging‐related pathologies
Due to its ability to accumulate over time [3], oxidative damage emerged as a consequence of longevity per se
The human life-span exceeds that of most mammalian species at least 4 times [7]
Summary
ΔAbstract: Multiple biological consequences of oxidative stress are known to contribute to aging and aging‐related pathologies. It is likely that the decrease in renewal of endothelial cells is a significant contributing factor to cardiovascular disorders of the aging blood vessels [15]. Carboxy-alkyl-pyrroles (CAPs) protein adducts have all the anticipated properties of the oxidative stress signature: they are generated as endproducts of lipid oxidation and are able to form stable conjugates with ECM proteins. CAP-induced angiogenesis may be considered as a part of coordinated tissue responses aimed to adapt to damaging conditions.
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