Abstract
Treatment of bovine pulmonary artery smooth muscle tissue microsomes with H 2O 2 (1 mM) markedly stimulated protease activity tested with a synthetic substrate N- benzoyl- dl-marginine p-nitroanilide (BAPNA), and also enhanced Ca 2+-ATPase activity. ATP-dependent Ca 2+ uptake was found to be stimulated upon treatment of the microsomes with H 2O 2. Pretreatment of the microsomes with vitamin E and aprotinin prevented the H 2O 2-induced stimulation of Ca 2+-ATPase activity and also ATP-dependent Ca 2+ uptake. In contrast, H 2O 2-induced inhibition of Na +-dependent Ca 2+ uptake was reversed by vitamin E and aprotinin.
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