Abstract
level of GPX (p=0.003), GST (P<0.001) and GSH (P=0.016) in DM1 patients. A significant negative correlation of MDA level with dyspepsia and CK-MB and GST level with serum SCK, CK-MB and diabetes were observed. However, a significant positive correlation of SOD level with serum CK-MB, CK-MM and diabetes and negative correlation with facial weakness were noted. Though, GSH level had significant positive correlation with learning and writing disability, speech and languages disability yet found negative correlation with duration of the disease. The GPX and TAS showed no correlation with any clinical findings.
Highlights
Oxidant–antioxidant imbalance in the serum of Myotonic Dystrophy type 1 (DM1) patients correlates with the progression of disease
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy affecting adults and is due to trinucleotide sequence (CTG) in the 3′ UTR region of DMPK gene located at 19q13.3 chromosome
Our data supports the pathogenic role of oxidative stress in DM1 of Indian origin and supports the opportunity to undertake clinical trials with antioxidants in this disorder
Summary
Oxidant–antioxidant imbalance in the serum of Myotonic Dystrophy type 1 (DM1) patients correlates with the progression of disease. From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. 23-25 January 2013
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