Abstract
Several lines of evidence derived from both in vitro and in vivo studies suggest an important role for reactive oxygen metabolites and glomerular pathophysiology. Both leukocytes and glomeruli have been shown to increase the generation of reactive oxygen metabolites in response to a wide variety of stimuli. Reactive oxygen metabolites generated enzymatically or by stimulated neutrophils have been shown to affect several biological processes of potential importance in glomerular injury, including glomerular basement degradation, eicosanoid synthesis, cyclic nucleotide metabolism, and glomerular ADPase activity. Scavengers of reactive oxygen metabolites have been shown to reduce proteinuria in several leukocyte-dependent and leukocyte-independent models of glomerular disease. Taken together, these studies suggest an important role of reactive oxygen metabolites in glomerular disease.
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