Abstract
Oxidant lung injury in cystic fibrosis
Highlights
In cystic fibrosis (CF) lung disease, the inflammatory response has been shown to be excessive relative to the burden of infection
The authors conclude that since the urinary excretion of 8-iso-PGF2a is elevated and correlated with lung function in CF, enhanced lipid peroxidation may play a role in disease progression
As 11-dehydro-TXB2 but not 8-iso-PGF2a excretion decreased with administration of COX inhibitors, enhanced lipid peroxidation by F2-isoprostanes is not due to persistent platelet activation, but rather may be due to a pro- and anti-oxidant imbalance in the CF lung
Summary
In cystic fibrosis (CF) lung disease, the inflammatory response has been shown to be excessive relative to the burden of infection. Aff[1] Case Western Reserve University School of Medicine, Cleveland, OH, USA Eicosanoids, isoprostanes, oxidants, peroxidation, prostaglandins, vitamin E Many of the inflammatory mediators result in oxidant lung injury.
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