Abstract
The influence of two organic selenocompounds and sodium selenite on oxidant processes in rat brain tissue was investigated. The study was performed on male Wistar rats. The animals were divided into four groups: I—control; II—administered with sodium selenite; III—provided with selenoorganic compound A of chain structure 4-(o-tolyl-)-selenosemicarbazide of 2-chlorobenzoic acid and IV—provided with selenoorganic compound B of ring structure 3-(2-chlorobenzoylamino-)-2-(o-tolylimino-)-4-methyl-4-selenazoline. Rats were treated by stomach tube at a dose of 5 × 10−4 mg of selenium/g of b.w. once a day for a period of 10 days. In brain homogenates total antioxidant status (TAS), activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), concentrations of ascorbic acid (AA) and reduced glutathione (GSH) as well as concentration of malonyl dialdehyde (MDA) were determined. TAS was insignificantly diminished in all selenium-supplemented groups versus control. SOD was not significantly influenced by administration of selenium. GPx was markedly decreased in group III versus control, whereas increased in group IV versus control and group III. Selenosemicarbazide depleted AA in well-marked way versus group II. GSH was significantly depressed in group III versus both control and group II and diminished in group IV versus group II. MDA was significantly decreased in group III versus both control and group II, whereas in group IV increased versus group III. As selenazoline A did not decrease elements of antioxidant barrier and increased GPx activity, it seems to be a promising agent for future studies concerning its possible application as a selenium supplement.
Highlights
Selenium is an essential trace element, necessary to correct organism’s functions (Yan et al 2013)
Activities of antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) were slightly increased versus control group in group II
In the case of GPx organic forms of selenium displayed insignificant differences when compared to inorganic selenite—in group III GPx was decreased versus group II, whereas in group IV enhancement versus group II was observed
Summary
Selenium is an essential trace element, necessary to correct organism’s functions (Yan et al 2013). The main difficulties result from the narrow range between therapeutic and toxic dose of selenium (Hawkes et al 2008) as well as from the dependence of its bioavailability on the form of supplementation (Burk et al 2006). A ring selenoorganic compound of isoselenazole structure has been found to possess antioxidant properties its negative effects have been stated (Farina et al 2004; Shi et al 2006). An organoselenium compound has been shown to exert protective effect against side effects of cisplatin by the affecting of pro- and antioxidative processes (Ghosh et al 2013)
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